Mine can be handled. However, even though I think he is more evenly tempered than most, and I have had years of practice at picking them up, I still really only handle him as required for cage cleaning. He will still bite, and he just doesn't enjoy being handled.
If you do get bitten, you always want to let the frog let go. If you pull it off, you could damage the teeth/jaws, and you're more likely to draw blood on your hand. Really, though, you should be much more afraid of your average kitten's bite than the bite of a good-sized pacman.
If you do need to pick them up, they usually aren't very quick or flexible. Distract them from the front, move in quickly and grab them securely from behind, but don't use too much pressure!
If you are really nervous, you could put something like a shallow deli cup in front of them, and use the lid to gently prod them in. This can be less succesful in older ones, who will just want to bury themselves deeper in the substrate and ignore you.
Good luck in deciding if this is the right pet for you!